• Background
  • Products
  • Literature
  • Videos
  • Resources

Paired Associative Stimulation

Paired-associative stimulation (PAS) represents a neurophysiologic paradigm that involves peripheral nerve stimulation (PNS) of the median nerve, followed by the transcranial magnetic stimulation (TMS) of the contralateral motor cortex.

Rizzo et al (2009) proved that corticocortical PAS can induce plasticity in connections between the targeted cortical areas, with its efficacy to induce lasting changes in excitability depending on the exact timing of the stimulus pairs. PAS has been shown to result in long-term potentiation-like activity (PAS-LTP) if PNS precedes TMS by 25 milliseconds (PAS-25). PAS-LTP has also been shown to relate to simple motor performance (Rajji et al. 2011).

References

  • Rizzo et al., Cereb Cortex, 2009.
  • Rajji et al., Brain Stimul, 2011.

Products

  • Magstim 200²
    A single pulse, monophasic stimulator used for cortical and peripheral stimulation.
  • Magstim BiStim² & Upgrade
    The BiStim² is an extension of the 200². Two of the single pulse systems are combined through a connecting module, so that paired pulses can be delivered through one coil.
  • Magstim Rapid², Super Rapid², & the Super Rapid² Plus¹
    The Magstim Rapid² is a single pulse and repetitive stimulator with high frequency capabilities. It is ideal for therapeutic applications as well as a wide variety of research fields.
  • Interface Module
    The Magstim Stimulator Interface Module provides additional interface functionality for all of the 2nd generation Magstim Stimulators (200², BiStim² and Rapid²).
  • Magstim Innovations
    Developed to meet research requirements, Magstim Innovations products can help push the boundaries of neuromodulation and brain stimulation with systems that meet your specific needs.
  • Double 70mm Coil
    The Double 70mm coil is capable of accurate stimulation of cortical areas and spinal nerve roots.
  • Double Cone Coil
    The Double Cone Coil elicits responses from relaxed muscles of the lower pelvic floor and lower limbs.
  • Articulated Coil Stand
    The Magstim Articulated Coil Stand arm is an elegant multi-movement mechanism capable of holding a stimulating coil over an exceptionally wide range of movement.

Literature

Video

Resources

More about us

About Us

Magstim provides the means for neuroscientists to work with the human brain in awake subjects by manufacturing and supplying state-of-the-art clinical and research instruments in the fields of:

    - Neurology
     - Neurophysiology
     - Psychiatry
     - Cognitive Neuroscience
     - ENT, Orthopaedics and Neurosurgery (this is managed by our Neurosign division - www.neurosign.com)

    Magstim equipment is able to work in conjunction with many measuring technologies (fMRI/ EEG /PET/Positioning systems) so that questions about brain function can be addressed.

    Through our machines, users can assess, protect and improve the function of the nervous system in a variety of clinical and research situations.

    Our principal products are the Magstim range of magnetic nerve stimulators.

    Other services we offer:

    - Magstim Innovations

    A service designed to help researchers and other users of magnetic stimulation find the best solutions to their problems.

    Distributors

    Distributors

    Magstim Distributors can be contacted through our Sales Office.