Scientific & Research Studies

Read the latest research articles and studies exploring the use of TMS in various disorders.

This section of the Knowledge Center provides examples of clinical research relating to the below psychological and neurological conditions. These research examples are provided for interest only and do not serve as a clinical guide or recommendation.

Scientific content remains the intellectual property of the authors. Magstim does not engage in generating, or editing scientific content presented in this Knowledge Center. Inclusion in the Knowledge Center should not be taken as an endorsement of scientific findings by Magstim. Please note: the use of Magstim devices for other than the cleared intended use is considered investigational.

Major Depressive Disorder (MDD)

Intermittent theta burst stimulation (iTBS) versus standard 10Hz repetitive transcranial magnetic stimulation (rTMS) in major depressive disorder (MDD)

This study aimed to compare the effectiveness, safety, and tolerability of the standard 10Hz FDA cleared protocol (37-minutes duration) to intermittent theta burst stimulation (iTBS; 3-minutes duration) for treatment-resistant MDD.
Major Depressive Disorder (MDD)

Theta burst stimulation (TBS) over the dorsolateral prefrontal cortices (DLPFCs) in major depressive disorder (MDD)

Data from 221 participants with MDD, across 5 randomized, single/double-blinded, sham-controlled trials were assessed regarding the efficacy of TBS over the DLPFC in terms of response and remission (Hamilton Depression Rating Scale).
Major Depressive Disorder (MDD)

Accelerated repetitive transcranial magnetic stimulation (rTMS) in major depressive disorder (MDD)

This study investigated whether accelerated rTMS could be as effective and tolerable as standard duration rTMS in 36 individuals with MDD. Patients were randomized to receive 3000 pulses of 10Hz stimulation to the left DLPFC either once a day (OD; n = 19) or twice a day (TD; n = 17) for a total of 30 sessions.
Major Depressive Disorder (MDD)

12-month follow-up of repetitive transcranial magnetic stimulation (rTMS) maintenance therapy in major depressive disorder (MDD)

This 12-month study examined whether monthly rTMS treatments were more effective than observation only in maintaining treatment response to rTMS therapy in non-medicated patients with MDD.
Major Depressive Disorder (MDD)

Accelerated intermittent theta burst (aiTBS) and individualised resting-state functional connectivity (fcMRI) targeting in treatment-resistant major depressive disorder (MDD)

Examine the feasibility, tolerability, and preliminary efficacy of an accelerated, high-dose, fcMRI-guided iTBS protocol for treatment-resistant depression (TRD) termed ÔÇśStanford Accelerated Intelligent Neuromodulation Therapy (SAINT)ÔÇÖ.
Anxiety

Low-frequency repetitive transcranial magnetic stimulation (rTMS) over the right dorsolateral prefrontal cortex (DLPFC) in generalized anxiety disorder (GAD)

In this small, randomized, double-blind, sham-controlled study, the authors examined the impact of 30 sessions of low-frequency (1 Hz) rTMS over the right DLPFC in treating GAD.
Anxiety

High-frequency rTMS over the right dorsolateral prefrontal cortex (DLPFC) in generalized anxiety disorder (GAD)

In this small, randomized, double-blind, sham-controlled study, the authors investigated the benefits of 25 sessions of high frequency (20Hz) rTMS over the right DLPFC for the treatment of GAD.
Post-traumatic Stress Disorder (PTSD)

Low-frequency repetitive transcranial magnetic stimulation (rTMS) over the right dorsolateral prefrontal cortex (DLPFC) in post-traumatic stress disorder (PTSD)

This randomized, double-blind, sham-controlled study investigated whether low frequency (1Hz) rTMS over the right DLPFC in combination with Cognitive Processing Therapy (CPT) is more effective in reducing PTSD symptoms than sham stimulation plus CPT.

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